Five Popular and Quintessential U.S. Road Trips
July 23, 2025
There’s something undeniably special about hitting the open road in the United States. From the vibrant cities to the serene countryside, the U.S. offers some of the best road trip routes in the world. Whether you’re a seasoned traveller or a first-timer, U.S. road trips are the perfect way to explore diverse landscapes and experience the local culture at your own pace.
In this guide, we’ll cover five popular and quintessential U.S. road trips that should be on every traveller’s bucket list. These road trips promise unforgettable views, historical landmarks, and the freedom to explore hidden gems along the way. Ready to get behind the wheel? Let’s dive into these must-do road trips across the United States!
1. Route 66: The Ultimate American Road Trip
Route 66, also known as the “Mother Road,” is one of the most famous U.S. road trips for a good reason. Stretching from Chicago, Illinois, to Santa Monica, California, this iconic highway offers a nostalgic journey through classic Americana.
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Highlights:
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Chicago to Santa Monica: The adventure begins in Chicago, where you can visit the Willis Tower Skydeck or enjoy the city’s deep-dish pizza. The route then takes you through the heart of America, with stops in towns like St. Louis, Missouri, and Albuquerque, New Mexico.
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Classic Attractions: Don’t miss the giant orange dinosaur at the Route 66 Museum, the Cadillac Ranch in Amarillo, Texas, or the Painted Desert in Arizona.
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Endless Charm: From quirky roadside diners to retro motels, the charm of Route 66 lies in its old-school feel and the memories it creates.
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Tips for Your Trip:
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Be prepared for extended periods of driving, primarily through the desert, where gas stations can be scarce.
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Download a Route 66 app to help guide you and provide information on the best attractions.
If you’re flying into Chicago to begin your adventure, book flight tickets from Los Angeles to Chicago for an easy start to your Route 66 journey.
2. Pacific Coast Highway: California’s Scenic Beauty
For those who love coastal views, the Pacific Coast Highway is one of the most scenic U.S. road trips you can take. Spanning from San Diego in the south to the majestic cliffs of Big Sur and up to the misty shores of Northern California, this road trip offers breathtaking views of the Pacific Ocean.
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Highlights:
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Big Sur: Drive along the cliffs of Big Sur, where the ocean crashes against rugged cliffs, and stop for a scenic hike or two.
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Santa Barbara: Known for its Mediterranean climate and beautiful beaches, Santa Barbara is the perfect stop for some relaxation.
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San Francisco: No trip is complete without a stop in San Francisco to see the Golden Gate Bridge, Fisherman’s Wharf, and Alcatraz Island.
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Tips for Your Trip:
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Plan for multiple stops at scenic viewpoints and beaches to fully experience the beauty of the coastline.
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Pack a light jacket as the weather can change quickly, especially in areas like San Francisco and Big Sur.
If you’re flying into California for this trip, book cheap round-trip flights from Michigan to California for a stress-free start.
3. Blue Ridge Parkway: Appalachian Charm
If you prefer a road trip through the mountains, the Blue Ridge Parkway is one of the best. This scenic highway stretches through Virginia and North Carolina, connecting the Great Smoky Mountains National Park with Shenandoah National Park.
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Highlights:
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Natural Beauty: Known for its stunning mountain views, lush forests, and vibrant fall foliage, the Blue Ridge Parkway offers one of the most peaceful U.S. road trips.
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Hiking and Waterfalls: The route features numerous hiking trails, including some that lead to stunning waterfalls, such as Linville Falls.
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Historic Sites: Stop by Mabry Mill in Virginia or visit the Blue Ridge Music Centre, which celebrates the region’s rich musical heritage.
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Tips for Your Trip:
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The Parkway can be steep and winding, so be prepared for slow driving, especially during peak tourist seasons.
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Be sure to bring your camera—there are so many photo-worthy moments along this road!
Flying in? Compare flight tickets from New York to North Carolina for a quick connection to the Blue Ridge Parkway.
4. The Great River Road: Exploring the Mississippi River
For a more relaxed road trip with rich history, the Great River Road follows the mighty Mississippi River through ten states, offering a unique mix of culture, history, and natural beauty.
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Highlights:
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Starting Point: Minnesota: Begin your journey near Lake Itasca in Minnesota, where the Mississippi River begins. Take a moment to visit the headwaters before you hit the road.
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New Orleans, Louisiana: No road trip along the Mississippi is complete without stopping in New Orleans. Explore the French Quarter, enjoy the live music, and savor the local cuisine.
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Historic Towns: The route takes you through historic cities like St. Louis, Missouri, and Natchez, Mississippi, where you can explore old mansions and battlefields.
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Tips for Your Trip:
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Plan your route around the seasons, as the Mississippi River can experience flooding in the spring, which may affect certain areas.
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Take the time to try local foods, such as gumbo in Louisiana or barbecue in Memphis, for an authentic experience.
For easy access to this scenic road, book flights from Alabama to New Orleans and get ready for a road trip complete of culture.
5. The Florida Keys: Tropical Paradise on Wheels
If you’re looking for a road trip with a more tropical flair, head down to the Florida Keys. This 113-mile-long chain of islands offers stunning views of the turquoise waters of the Atlantic Ocean, along with a laid-back vibe perfect for a relaxing escape.
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Highlights:
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Key Largo: Known for its beautiful coral reefs, Key Largo is a haven for divers and snorkelers. It’s also a great spot to kick off your Florida Keys adventure.
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Key West: The southernmost point of the U.S., Key West is full of quirky charm. Visit Ernest Hemingway’s house, enjoy a sunset at Mallory Square, and sip on a mojito at a local bar.
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Scenic Bridges: The drive itself is unforgettable, with views of the ocean on both sides of the highway. The Seven Mile Bridge offers an iconic, breathtaking view.
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Tips for Your Trip:
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The Florida Keys are popular during winter, so plan if you want to avoid the crowds.
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Don’t forget to stop at some of the local seafood joints for the freshest fish you’ll ever taste.
For a hassle-free experience, book flight tickets from Miami to Florida Keys and enjoy a tropical escape.
Conclusion
The U.S. offers some of the best road trip routes that combine scenic beauty, historical landmarks, and unforgettable experiences. Whether you’re cruising down Route 66, soaking in the coastal views along the Pacific Coast Highway, or enjoying the mountainous beauty of the Blue Ridge Parkway, these U.S. road trips offer something for everyone.
Each road trip provides unique opportunities to explore different parts of the country at your own pace. So, pack your bags, hit the road, and start creating memories on one of these incredible routes. Don’t forget to book your flights in advance for the best deals and travel stress-free!